Description

(S)-1-[N2-(1-Carboxy-3-Phenylpropyl)-L-Lysyl]-L-Proline Disulphate is a high-purity, non-peptide angiotensin-converting enzyme (ACE) inhibitor intermediate of significant pharmaceutical importance. This compound is critical for the synthesis of advanced active pharmaceutical ingredients (APIs) targeting cardiovascular conditions. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of antihypertensive and heart failure medications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced ACE inhibitor APIs, such as Lisinopril and related analogs.
• Cardiovascular Drug Research: Used in preclinical and clinical research for developing new therapeutic agents for hypertension and congestive heart failure.
• Process Development & Scale-up: Serves as a critical reference standard and starting material for process chemistry optimization in GMP manufacturing.
• Analytical Reference Standard: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.
• Biochemical Studies: Used in enzymatic studies to investigate the mechanism of action and specificity of ACE inhibition.

Basic Information

Product Name	(S)-1-[N2-(1-Carboxy-3-Phenylpropyl)-L-Lysyl]-L-Proline Disulphate
CAS No.	82009-35-6
Molecular Formula	C21H31N3O5 • 2H2SO4
Molecular Weight	621.68 g/mol
Synonyms	Lisinopril Disulphate; Lisinopril Dihydrogen Sulfate; (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-proline sulfate (2:1); N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline disulfate salt; SQ 14225 Disulphate; MK-521 Disulphate; Prinivil Intermediate; Zestril Intermediate
EINECS	Contact for details

Quality Control

Our (S)-1-[N2-(1-Carboxy-3-Phenylpropyl)-L-Lysyl]-L-Proline Disulphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with pharmaceutical intermediate standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Ensure the storage area is well-ventilated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Optical Rotation	[α]20/D: Specific range provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.