Description

(+)-Nitrendipine CAS NO 80890-07-9 is the pharmacologically active enantiomer of the dihydropyridine calcium channel blocker Nitrendipine. This high-purity chiral intermediate is critical for research and development in cardiovascular pharmacology, offering superior specificity for studying receptor interactions and metabolic pathways. It is primarily required by pharmaceutical R&D laboratories, analytical reference standard producers, and advanced fine chemical synthesis units focused on developing next-generation antihypertensive agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, GC-MS) for quality control of bulk Nitrendipine and related formulations.
• Cardiovascular Research: Serves as a key chiral tool for in vitro and in vivo studies targeting L-type calcium channels, aiding in the investigation of hypertension and angina mechanisms.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand the disposition and activity of the (+)-enantiomer separately from the racemic mixture.
• Chiral Synthesis: Acts as a premium starting material or intermediate for the synthesis of novel, enantiomerically pure dihydropyridine derivatives with potential therapeutic applications.
• Biochemical Assay Development: Utilized in developing high-throughput screening assays and binding studies to evaluate compound interactions with specific calcium channel subunits.

Basic Information

Product Name	(+)-Nitrendipine
CAS No.	80890-07-9
Molecular Formula	C18H20N2O6
Molecular Weight	360.36 g/mol
Synonyms	(+)-Nitrendipine; (R)-(+)-Nitrendipine; Dextro-Nitrendipine; (3R,5R)-Nitrendipine; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester; Bay e 5009; Bayotensin; (R)-BAY e 5009
EINECS	Contact for details

Quality Control

Our (+)-Nitrendipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting standards for research and development use. A detailed Certificate of Analysis (COA) providing full specification results is supplied with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.