Description

Indolapril is an angiotensin-converting enzyme (ACE) inhibitor, a critical active pharmaceutical ingredient (API) in the treatment of hypertension and heart failure. Its primary value lies in its potent and specific inhibition of ACE, which regulates blood pressure and cardiovascular function. This compound is essential for pharmaceutical manufacturers developing generic and branded cardiovascular medications, as well as for research institutions conducting pharmacological studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive and heart failure medications.
• Generic Drug Formulation: Key component for manufacturers producing cost-effective generic versions of ACE inhibitor drugs.
• Clinical Research: Used in preclinical and clinical studies to investigate cardiovascular pharmacology and new therapeutic applications.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in laboratories.
• Bulk Pharmaceutical Intermediates: May be utilized in the synthesis of more complex pharmaceutical compounds or prodrugs.

Basic Information

Product Name	Indolapril
CAS No.	80876-01-3
Molecular Formula	C22H28N2O4
Molecular Weight	384.47 g/mol
Synonyms	Indolapril; Indolaprilum; (S)-1-[N2-(1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl]indoline-2-carboxylic acid; 2-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-1,3-dihydroindole-2-carboxylic acid; SE 9500; SQ 26991; Indolapril Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Indolapril is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Quality is assured through comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, IR, and other pharmacopeial methods. We provide full traceability and Certificates of Analysis (COA) are available for every batch, confirming compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.