Description

(-)-Nitrendipine CAS NO 80873-62-7 is the enantiomerically pure form of the well-known dihydropyridine calcium channel blocker. This high-purity chiral compound is a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for the synthesis of enantiopure active pharmaceutical ingredients (APIs) and for analytical method development.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of enantiomerically pure cardiovascular drugs and other therapeutic agents.
• Reference Standard: Used for analytical method validation, calibration, and quality control testing in pharmaceutical laboratories to ensure product purity and regulatory compliance.
• Biochemical Research: Employed as a selective L-type calcium channel antagonist in pharmacological and physiological studies to investigate cellular signaling pathways.
• Process Development: Serves as a critical material in the development and optimization of asymmetric synthesis routes and chiral separation processes.
• Impurity Standard: Used to identify and quantify the (-)-enantiomer as a potential impurity in batches of racemic nitrendipine or its (+)-enantiomer.

Basic Information

Product Name	(-)-Nitrendipine
CAS No.	80873-62-7
Molecular Formula	C18H20N2O6
Molecular Weight	360.36 g/mol
Synonyms	(-)-Nitrendipine; (S)-Nitrendipine; (S)-(-)-Nitrendipine; (S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester; Bayotensin; Bay e 5009; NSC 344331; (S)-3-Ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
EINECS	Contact for details

Quality Control

Our (-)-Nitrendipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.