Description

Calcium Levofolinate is the calcium salt of the active isomer of folinic acid, a vital biochemical intermediate. This high-purity compound is critical for ensuring precise biochemical activity in advanced pharmaceutical formulations. It is primarily utilized by manufacturers in the pharmaceutical and biotechnology sectors for producing rescue therapies and specialized chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: A key starting material in the synthesis of high-value active pharmaceutical ingredients (APIs).
• Oncology Therapeutics: Used in the formulation of rescue agents to counteract the toxic effects of methotrexate and other folate antagonist chemotherapy drugs.
• Biochemical Research: Serves as a critical reagent in enzymatic studies and cell culture media requiring specific folate sources.
• Advanced Drug Delivery Systems: Incorporated into targeted delivery mechanisms due to its specific biochemical role.
• Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in QC laboratories.

Basic Information

Product Name	Calcium Levofolinate
CAS No.	80433-71-2
Molecular Formula	C20H21CaN7O7
Molecular Weight	511.51 g/mol
Synonyms	Calcium (6S)-5,6,7,8-Tetrahydrofolate; (6S)-5,6,7,8-Tetrahydrofolic Acid Calcium Salt; Leucovorin Calcium (Isomer); Levoleucovorin Calcium; (6S)-Leucovorin Calcium; (6S)-5-Formyl-5,6,7,8-tetrahydrofolic Acid Calcium Salt; (6S)-Folinic Acid Calcium Salt
EINECS	Contact for details

Quality Control

Our Calcium Levofolinate is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical applications, with comprehensive analysis including chiral purity to confirm the correct isomeric form. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0% (6S)-isomer
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.