Description

Zoledronicacid CAS NO 118054-40-3 is a highly potent nitrogen-containing bisphosphonate compound. It is a critical active pharmaceutical ingredient (API) primarily valued for its powerful inhibitory effect on osteoclast-mediated bone resorption. This makes it essential for the formulation of injectable pharmaceuticals targeting severe bone disorders. Key industrial users include pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) focused on osteoporosis and oncology treatments.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for treating osteoporosis and Paget's disease of bone.
• Oncological Therapeutics: Used in medications to prevent skeletal-related events (SREs) such as fractures and spinal cord compression in patients with bone metastases from solid tumors.
• Hypercalcemia of Malignancy: Formulated for drugs that treat high calcium levels in the blood caused by certain cancers.
• Research & Development: Serves as a key reference standard and biochemical tool in metabolic bone disease research and drug discovery programs.
• Veterinary Medicine: Investigated for applications in managing bone conditions in companion and livestock animals.

Basic Information

Product Name	Zoledronicacid
CAS No.	118054-40-3
Molecular Formula	C5H10N2O7P2
Molecular Weight	272.09 g/mol (Anhydrous)
Synonyms	Zoledronic Acid; Zoledronate; CGP 42446; (1-Hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid; Zometa (brand name); Reclast (brand name); Aclasta (brand name); IUPAC: (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(phosphonic acid)
EINECS	Contact for details

Quality Control

Our Zoledronic Acid is manufactured under strict quality management systems. It is typically produced to meet high-purity standards suitable for pharmaceutical applications, with specifications aligned with major pharmacopoeial guidelines. Certificates of Analysis (COA) are provided with each batch, detailing key parameters such as assay, purity, and impurity profiles. We ensure compliance with relevant GMP principles and can support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
pH (1% Solution)	2.0 - 3.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.