Description

Biricodar is a third-generation, potent, and selective modulator of P-glycoprotein (P-gp) and other multidrug resistance-associated proteins (MRPs). This compound is of significant interest in pharmaceutical research for its potential to reverse multidrug resistance (MDR) in cancer cells, thereby enhancing the efficacy of chemotherapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and development, as well as in academic studies investigating the mechanisms of drug efflux and resistance.

Application

• Oncology Research: Used as a key pharmacological tool to study and overcome multidrug resistance in various cancer cell lines.
• Drug Discovery & Development: Serves as a reference standard and active agent in preclinical studies for developing novel combination cancer therapies.
• Mechanistic Studies: Employed in biochemical and cellular assays to investigate the function and inhibition of P-glycoprotein and related efflux transporters.
• In vitro Pharmacology: Applied in cell-based screening platforms to evaluate the sensitization of resistant tumors to standard chemotherapeutics.
• Academic Research: Utilized in university and institutional labs for fundamental research on membrane transport proteins and cancer biology.
• Biomarker Research: Potential use in studies correlating transporter expression with treatment outcomes.

Basic Information

Product Name	Biricodar
CAS No.	159997-94-1
Molecular Formula	C34H41N3O5
Molecular Weight	571.71 g/mol
Synonyms	VX-710; NSC 725403; Biricodar dicitrate; 1-Naphthalenepentanoic acid, α-[[(2S,4R,6E)-4-[(2,6-dimethoxy-4-methylphenyl)thio]-4-methyl-6-(2-oxo-1-pyrrolidinyl)-2-hexenyl]thio]-, (αS)-; P-gp/MRP modulator VX-710; S9788; Multidrug resistance modulator VX-710
EINECS	Contact for details

Quality Control

Our Biricodar is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.