Description

Amifostine Thiol Dihydrochloride is the active metabolite of the cytoprotective agent amifostine, functioning as a potent free radical scavenger. This compound is critical for research and development in pharmaceutical applications, particularly in mitigating the toxic side effects of chemotherapy and radiation therapy on healthy tissues. It is primarily utilized by pharmaceutical manufacturers, academic research institutions, and biotechnology companies focused on oncology and radioprotection.

Application

• Pharmaceutical Intermediate: Key raw material in the synthesis of cytoprotective drugs and related active pharmaceutical ingredients (APIs).
• Oncology Research: Investigated for its role in protecting non-cancerous cells from the damaging effects of chemotherapy and radiation treatment.
• Radioprotective Agent Development: Serves as a reference standard and active component in preclinical studies for developing new radioprotectants.
• Biochemical Research: Used in studies exploring mechanisms of oxidative stress, apoptosis, and cellular damage pathways.
• Reference Standard: Employed in analytical laboratories for quality control and method development using HPLC, LC-MS, or NMR.

Basic Information

Product Name	Amifostine Thiol Dihydrochloride
CAS No.	14653-77-1
Molecular Formula	C5H15N2O3PS • 2HCl
Molecular Weight	307.09 g/mol (for dihydrochloride salt)
Synonyms	WR-1065 Dihydrochloride; Ethiofos Thiol Dihydrochloride; 2-[(3-Aminopropyl)amino]ethanethiol Dihydrochloride; Amifostine Active Metabolite; S-2-(3-Aminopropylamino)ethylphosphorothioic Acid Thiol Dihydrochloride; Gammaphos Thiol Dihydrochloride; NSC-689534 Dihydrochloride
EINECS	Contact for details

Quality Control

Our Amifostine Thiol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.