Description

Dofequidar (R)-Isomer is the optically pure (R)-enantiomer of the potent P-glycoprotein inhibitor Dofequidar, a key compound in pharmaceutical research and development. This high-purity isomer is critical for studying stereospecific drug interactions, particularly in overcoming multidrug resistance in cancer therapy. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced oncology research, drug metabolism studies, and the development of novel chemosensitizers.

Application

• Pharmaceutical R&D: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of P-glycoprotein inhibitors.
• Oncology Research: Used in preclinical studies to investigate mechanisms for reversing multidrug resistance (MDR) in cancer cell lines.
• Metabolism and Pharmacokinetics: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the stereoselective behavior of drug candidates.
• Analytical Standard: Functions as a high-purity certified reference material (CRM) for method development and validation in chiral chromatography.
• Biochemical Assays: Applied in vitro assays to study the specific binding and inhibition potency of the (R)-enantiomer versus its counterpart.

Basic Information

Product Name	Dofequidar (R)-Isomer
CAS No.	153653-33-9
Molecular Formula	C32H31N3O5
Molecular Weight	537.61 g/mol
Synonyms	(R)-Dofequidar; (R)-MS-209; (R)-3,6-Bis[2-(1-piperidinyl)ethoxy]-2-(6-methoxy-2-naphthyl)benzofuran; (R)-MS209; (R)-Enantiomer of MS-209; (R)-Benzofuran derivative MS209; (R)-Chemosensitizer MS209
EINECS	Contact for details

Quality Control

Our Dofequidar (R)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates used in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.