Description

Tariquidar Dihydrochloride is a potent and selective third-generation P-glycoprotein (P-gp) inhibitor, widely recognized for its role in overcoming multidrug resistance (MDR) in cancer therapy. Its primary value lies in its ability to enhance the intracellular accumulation and efficacy of co-administered chemotherapeutic agents by blocking their efflux from cancer cells. This makes it a critical research tool and a promising candidate for pharmaceutical development, particularly for researchers and manufacturers in oncology, pharmacology, and drug delivery systems. The compound is supplied under strict quality control to ensure reliable and reproducible results in preclinical and clinical studies.

Application

• Oncology Research: Used as a P-gp inhibitor to study and overcome multidrug resistance in various cancer cell lines and animal models.
• Pharmacokinetic Studies: Employed to investigate the blood-brain barrier penetration and bioavailability of co-administered drugs.
• Pharmaceutical Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the formulation of novel combination therapies.
• Biochemical Assays: Utilized in in vitro assays to characterize P-gp transporter activity and inhibition mechanisms.
• Academic Research: Applied in university and institutional labs for fundamental studies on transporter proteins and cellular efflux mechanisms.
• Preclinical Testing: An essential component in drug discovery pipelines for evaluating the efficacy of new chemotherapeutic candidates in resistant cancers.

Basic Information

Product Name	Tariquidar Dihydrochloride
CAS No.	1992047-62-7
Molecular Formula	C₃₄H₃₅Cl₂N₃O₆ • 2HCl
Molecular Weight	726.5 g/mol (free base: 620.56 g/mol)
Synonyms	XR9576 Dihydrochloride; Tariquidar 2HCl; N-(2-{[4-(2,6-Dimethylphenyl)piperazin-1-yl]carbonyl}phenyl)-3,4,5-trimethoxybenzamide Dihydrochloride; Anthranilamide, N-[2-[[4-(2,6-dimethylphenyl)-1-piperazinyl]carbonyl]phenyl]-3,4,5-trimethoxy-, dihydrochloride; P-gp Inhibitor XR9576; Multidrug Resistance Inhibitor XR9576; P-glycoprotein Antagonist Tariquidar.
EINECS	Contact for details

Quality Control

Our Tariquidar Dihydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications such as assay, impurity profile, and residual solvents. We support research and development with material suitable for use as a pharmaceutical reference standard. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.