Description

Dofequidar Fumarate CAS NO 153653-30-6 is a high-purity, small molecule pharmaceutical compound primarily utilized as a P-glycoprotein (P-gp) inhibitor. It is a critical research and development material for overcoming multidrug resistance (MDR) in cancer therapy. This compound is essential for pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in oncology drug discovery and formulation development.

Application

• Oncology Research: Key component in studies aimed at reversing multidrug resistance in cancer cell lines by inhibiting P-glycoprotein efflux pumps.
• Pharmaceutical Development: Used in the formulation and preclinical testing of novel chemotherapeutic agents to enhance their bioavailability and efficacy.
• Biochemical Assays: Serves as a reference standard and active agent in in vitro and in vivo models for evaluating drug transport mechanisms.
• Academic Research: Utilized in university and institutional labs for fundamental research on membrane transporters and their role in pharmacokinetics.
• Drug Combination Studies: Investigated in combination with established chemotherapeutic drugs to assess potential synergistic effects and improved treatment outcomes.

Basic Information

Item	Detail
Product Name	Dofequidar Fumarate
CAS No.	153653-30-6
Molecular Formula	C32H38N4O6
Molecular Weight	574.67 g/mol
Synonyms	MS-209; Dofequidar; MS 209; (R)-5-[[(2S)-3,4-Dihydro-2H-1-benzopyran-2-yl]methylamino]-2-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]ethyl 2-quinolinecarboxylate fumarate; Fumaric acid - 5-[[(2S)-3,4-dihydro-2H-1-benzopyran-2-yl]methylamino]-2-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]ethyl quinoline-2-carboxylate (1:1)
EINECS	Contact for details

Quality Control

Our Dofequidar Fumarate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.