Description

Uproleselan Sodium is a high-purity, small molecule pharmaceutical compound with the CAS registry number 1914993-95-5. This compound is a selective E-selectin antagonist, offering significant value in targeted therapeutic research and development. It is primarily required by pharmaceutical companies and research institutions engaged in advanced oncology and hematology studies, particularly for investigating treatments for acute myeloid leukemia (AML) and other conditions involving leukocyte adhesion and migration.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key active component in investigational new drug (IND) formulations targeting E-selectin.
• Oncology Research: Critical for preclinical and clinical research focused on disrupting cancer cell adhesion and metastasis, especially in acute myeloid leukemia (AML).
• Hematology Studies: Used in studies investigating leukocyte trafficking, inflammation, and sickle cell disease pathology.
• Drug Discovery & Development: A vital reference standard and building block in medicinal chemistry programs for developing novel anti-adhesion therapies.
• Biochemical Assays: Employed as a selective inhibitor in in vitro and in vivo assays to study E-selectin function and validate drug targets.
• GMP Manufacturing: Supplied as a starting material or intermediate for the cGMP-compliant production of clinical trial materials.

Basic Information

Product Name	Uproleselan Sodium
CAS No.	1914993-95-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Uproleselan Sodium Salt; GMI-1271 (Sodium Salt); E-Selectin Antagonist Uproleselan; (2S,3R,4S,5S,6R)-2-[[(3S,4R,5R)-4,5-Dihydroxy-1-(4-hydroxyphenyl)-3-(2-methoxyethoxy)pentyl]amino]-6-(hydroxymethyl)oxane-3,4,5-triol Sodium Salt; 1914993-95-5; GMI 1271 Sodium; Uproleselan (Sodium Form)
EINECS	Contact for details

Quality Control

Our Uproleselan Sodium is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods, and rigorous control of impurities. A Certificate of Analysis (COA) is provided with each shipment, detailing all test results against predefined specifications. We support development from non-GMP research to cGMP-grade material for clinical supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residue on Ignition	Contact for details
Heavy Metals	<20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.