Description

Anifostine Trihydrate is a cytoprotective agent and a prodrug of the active metabolite WR-1065. This compound is of significant commercial and research interest due to its selective protective effects on normal tissues against the toxicities of chemotherapy and radiation, without compromising the anti-tumor efficacy. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of chemoprotective and radioprotective formulations, as well as in advanced clinical research. Its unique mechanism of action makes it a critical component in studies aimed at improving therapeutic outcomes in oncology.

Application

• Pharmaceutical Active Ingredient (API): Used in the formulation of cytoprotective drugs to mitigate side effects of chemotherapy and radiotherapy.
• Radioprotective Agent Development: A key component in research and development of agents designed to protect healthy tissues during radiation therapy.
• Chemoprotective Studies: Employed in preclinical and clinical research to study mechanisms of selective tissue protection against cytotoxic drugs.
• Biochemical Research: Used as a standard or reagent in studies involving thiol metabolism, oxidative stress, and cellular protection pathways.
• Oncology Supportive Care: Investigated for use in supportive care protocols to improve patient tolerance to aggressive cancer treatments.

Basic Information

Product Name	Anifostine Trihydrate
CAS No.	112901-68-5
Molecular Formula	C5H15N2O3PS • 3H2O
Molecular Weight	278.23 g/mol (Anhydrous basis: 222.23)
Synonyms	Ethiofos; Ethyol (brand name); WR-2721 Trihydrate; S-2-(3-Aminopropylamino)ethylphosphorothioate Trihydrate; Amifostine Trihydrate; Gammaphos; NSC-296961 Trihydrate; 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate (Ester) Trihydrate
EINECS	Contact for details

Quality Control

Our Anifostine Trihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and water content are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	18.0% - 22.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Meets Ph. Eur. criteria for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.