Description

Dofequidar (S)-Isomer CAS NO 153653-31-7 is the specific enantiomer of the P-glycoprotein inhibitor Dofequidar, characterized by its distinct stereochemistry. This high-purity chiral building block is critical for advanced pharmaceutical research, particularly in the development of targeted therapies to overcome multidrug resistance in cancer treatment. It is essential for medicinal chemists, process development scientists, and research institutions focused on oncology drug discovery and pharmacokinetic optimization.

Application

• Pharmaceutical Research & Development: Serves as a key chiral intermediate in the synthesis of novel P-glycoprotein (P-gp) inhibitors for preclinical and clinical studies.
• Oncology Drug Discovery: Used to investigate and develop compounds aimed at reversing multidrug resistance (MDR) in various cancer cell lines.
• Medicinal Chemistry: A critical reference standard and building block for structure-activity relationship (SAR) studies to optimize efficacy and reduce toxicity.
• Pharmacokinetic Studies: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the enantiomer-specific behavior of drug candidates.
• Process Chemistry: Used in the development and scale-up of enantioselective synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: A valuable tool for universities and research institutes studying transporter proteins and mechanisms of chemoresistance.

Basic Information

Product Name	Dofequidar (S)-Isomer
CAS No.	153653-31-7
Molecular Formula	C32H31N3O5
Molecular Weight	537.61 g/mol
Synonyms	(S)-Dofequidar; (S)-MS-209; (S)-3(R),6(R)-5(S)-6(S)-8(R)-9(R)-MS-209; (S)-Enantiomer of MS-209; (S)-Enantiomer of Dofequidar; (S)-Quinoline derivative MS-209; (S)-6,7-Dimethoxy-2-{2-[(4-(2-pyridylamino)-7-quinolinyl]oxy}ethyl-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our Dofequidar (S)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.