Description

Dimesna is a synthetic organosulfur compound, also known as disodium 2,2'-dithio-bis-ethanesulfonate, primarily utilized as a cytoprotective agent. Its core value proposition lies in its ability to act as a selective detoxifying agent, protecting healthy tissues from the adverse effects of certain chemotherapeutic drugs and radiation therapy. This makes it a critical component in the formulation of uroprotective and chemoprotective pharmaceutical products. Industries requiring high-purity intermediates for advanced therapeutic applications are the primary end-users of this material.

Application

• Pharmaceutical Intermediate: Key raw material in the synthesis of Mesna (sodium 2-mercaptoethanesulfonate), a widely used detoxifying agent.
• Uroprotective Agent Production: Used in formulations designed to prevent hemorrhagic cystitis, a side effect of oxazaphosphorine chemotherapy drugs like ifosfamide and cyclophosphamide.
• Chemoprotective Formulations: Incorporated into therapeutic protocols to mitigate the toxicity of platinum-based and other chemotherapeutic agents on renal and other tissues.
• Research & Development: Serves as a standard or reference compound in pharmacological and toxicological studies focused on cytoprotection and detoxification pathways.
• Biochemical Reagent: Employed in laboratory settings to study thiol-disulfide exchange reactions and redox biochemistry.

Basic Information

Product Name	Dimesna
CAS No.	16208-51-8
Molecular Formula	C4H6Na2O6S4
Molecular Weight	332.30 g/mol
Synonyms	Disodium 2,2'-dithiobis(ethanesulfonate); BNPT; Dimesna disodium; Tavocept; 2,2'-Dithiobis(ethanesulfonic acid) disodium salt; Disodium 2,2'-dithiodiethanesulfonate; BNP7787
EINECS	240-317-9

Quality Control

Our Dimesna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay, purity by HPLC, identification, and impurity profiles. We can support compliance with relevant pharmacopeial standards (e.g., USP, EP) for specific grades upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect product stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.