Description

n-[4-[[(2-Amino-5-Formyl-1,4,5,6,7,8-Hexahydro-4-Oxo-6-Pteridinyl)Methyl]Amino]Benzoyl]-L-Glutamic Acid Disodium Salt is a high-purity, chemically defined folate derivative of significant importance in advanced biochemical research and pharmaceutical development. This compound serves as a critical reference standard and a key synthetic intermediate for the production of novel folate analogs and targeted therapeutic agents. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require precise, high-quality building blocks for drug discovery and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified primary standard for the quality control and assay of folate-based drugs and formulations.
• Biochemical Research: Serves as a crucial intermediate in the study of folate metabolism, enzyme inhibition, and one-carbon transfer pathways.
• Active Pharmaceutical Ingredient (API) Synthesis: A key precursor in the multi-step synthesis of novel antifolate drugs and targeted cancer therapeutics.
• Diagnostic Reagent Development: Employed in the formulation of high-sensitivity assay kits for folate detection and related metabolic diagnostics.
• Academic & Institutional Research: Provides a well-characterized compound for universities and research institutes exploring vitamin biochemistry and drug design.
• Process Development & Scale-up: Supports process chemistry teams in optimizing synthetic routes for GMP-grade production of complex folate molecules.

Basic Information

Product Name	n-[4-[[(2-Amino-5-Formyl-1,4,5,6,7,8-Hexahydro-4-Oxo-6-Pteridinyl)Methyl]Amino]Benzoyl]-L-Glutamic Acid Disodium Salt
CAS No.	163254-40-8
Molecular Formula	C23H24N8Na2O7
Molecular Weight	570.47 g/mol
Synonyms	5,6,7,8-Tetrahydrofolic acid, 5-formyl-, N-[p-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid disodium salt; 5-Formyl-5,6,7,8-tetrahydrofolic acid disodium salt; Folinic acid disodium salt (specific isomer); Leucovorin disodium salt analog; (6S)-5,6,7,8-Tetrahydrofolic acid, 5-formyl-, disodium salt; N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]-L-glutamic acid disodium salt; 5-CHO-THF disodium salt.
EINECS	Contact for details

Quality Control

Our n-[4-[[(2-Amino-5-Formyl-1,4,5,6,7,8-Hexahydro-4-Oxo-6-Pteridinyl)Methyl]Amino]Benzoyl]-L-Glutamic Acid Disodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and development standards. Specifications can be aligned with client requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a cool, dry place to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
pH (1% Solution)	6.5 - 8.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.