Description

Lomeguatrib is a potent and selective inhibitor of O6-alkylguanine-DNA alkyltransferase (AGT), a key DNA repair protein. This compound is crucial for research and development in oncology, as it is used to sensitize tumor cells to the cytotoxic effects of alkylating chemotherapeutic agents. It is an essential biochemical tool for pharmaceutical R&D, academic research, and preclinical studies focused on overcoming chemotherapy resistance.

Application

• Chemotherapy Sensitizer Research: Used in preclinical studies to enhance the efficacy of alkylating agents like temozolomide and carmustine (BCNU) by inhibiting the AGT-mediated DNA repair pathway in cancer cells.
• Oncology Drug Development: A critical research chemical for screening and developing novel combination therapies aimed at overcoming tumor resistance mechanisms.
• Biochemical Mechanism Studies: Employed in academic and institutional laboratories to investigate DNA damage and repair processes, cellular response to genotoxic stress, and apoptosis signaling.
• In Vitro & In Vivo Models: Utilized in cell-based assays and animal models to evaluate the potential of AGT inhibition as a therapeutic strategy for glioblastoma, melanoma, and other resistant cancers.

Basic Information

Product Name	Lomeguatrib
CAS No.	192441-08-0
Molecular Formula	C10H13N5O2S
Molecular Weight	267.31 g/mol
Synonyms	O6-Benzylguanine; O6-BG; O6-(Benzyl)guanine; Lomeguatrib Hydrochloride (salt form); AGT Inhibitor; NSC 637037; CCRG 81045; PF-06463922 (related development code)
EINECS	Contact for details

Quality Control

Our Lomeguatrib is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with research standards and can provide material for method development and validation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥98.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.