Description

Trilaciclib CAS NO 1374743-00-6 is a highly selective, reversible cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. This small molecule pharmaceutical compound is of significant interest for its cytoprotective role in preserving hematopoietic stem and progenitor cells during chemotherapy. It is primarily targeted at research institutions, pharmaceutical developers, and manufacturers engaged in oncology drug discovery and the production of advanced therapeutic agents for cancer treatment.

Application

• Oncology Research & Drug Development: A key investigational agent for studying myeloprotection and chemoprotection mechanisms in preclinical and clinical cancer models.
• Pharmaceutical Intermediates: Serves as a critical active pharmaceutical ingredient (API) in the formulation of novel chemoprotective therapies.
• Biochemical Research: Used as a selective inhibitor to probe CDK4/6 pathway dynamics and cell cycle regulation in various cellular assays.
• Clinical Trial Materials (CTM): Supplied under GMP guidelines for use in clinical studies evaluating its efficacy in reducing chemotherapy-induced myelosuppression.
• Reference Standard: High-purity grades are utilized as analytical reference standards in quality control laboratories for method development and validation.

Basic Information

Product Name	Trilaciclib
CAS No.	1374743-00-6
Molecular Formula	C₂₆H₂₇F₂N₇O₃
Molecular Weight	523.54 g/mol
Synonyms	G1T28; Trilaciclib dihydrochloride; 4-[[4-[[(3S)-3-Methyl-4-morpholinyl]methyl]-2-pyridinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]pyrimidine-2-carboxamide; Cosela (brand name); CDK 4/6 Inhibitor G1T28; G1T-28; BMS-986158 (former code)
EINECS	Contact for details

Quality Control

Our Trilaciclib is manufactured and tested under a rigorous quality management system. We provide material that meets high-purity standards suitable for research and development, with options available under current Good Manufacturing Practice (cGMP) for advanced applications. Comprehensive testing includes identity, purity (by HPLC), and impurity profiling. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.