Description

1,4-Dihydro-2,6-Dimethyl-4-(3-Methylphenyl)-3,5-Pyridinedicarboxylic Acid Dimethyl Ester is a high-purity dihydropyridine derivative, a key structural motif in pharmaceutical chemistry. This compound is valued for its role as a critical advanced pharmaceutical intermediate in the synthesis of calcium channel blockers and other active pharmaceutical ingredients (APIs). It is essential for R&D laboratories and manufacturing facilities focused on developing and producing cardiovascular therapeutics and novel drug candidates.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of Nifedipine analogs and other 1,4-dihydropyridine-class calcium channel blockers.
• Research & Development: Key starting material (KSM) or intermediate in medicinal chemistry for exploring new cardiovascular and neurological drug candidates.
• API Synthesis: Used in the controlled, multi-step manufacturing processes of finished dosage form active ingredients.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization studies for more efficient and scalable API production.

Basic Information

Product Name	1,4-Dihydro-2,6-Dimethyl-4-(3-Methylphenyl)-3,5-Pyridinedicarboxylic Acid Dimethyl Ester
CAS No.	80307-08-0
Molecular Formula	C18H21NO4
Molecular Weight	315.36 g/mol
Synonyms	Dimethyl 2,6-Dimethyl-4-(3-Methylphenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate; 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Methylphenyl)-, Dimethyl Ester; 4-(3-Methylphenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylic Acid Dimethyl Ester; 3-Methylphenyl DHP Derivative; DHP Ester Intermediate; Nifedipine Related Compound; Hantzsch Ester Derivative
EINECS	Contact for details

Quality Control

Our 1,4-Dihydro-2,6-Dimethyl-4-(3-Methylphenyl)-3,5-Pyridinedicarboxylic Acid Dimethyl Ester is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.