Description

(Z)-Cinnarizine is a specific stereoisomer of the well-known pharmaceutical compound cinnarizine, identified by CAS NO 750512-44-8. This high-purity isomer is of significant interest for advanced pharmaceutical research and development, particularly in the study of structure-activity relationships and the development of more selective therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing next-generation treatments for vestibular disorders and improving drug efficacy profiles.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the research-scale synthesis and process development of stereospecific cinnarizine-based formulations.
• Mechanistic & Pharmacological Studies: Essential for preclinical research investigating the specific biological activity, metabolism, and receptor binding affinity of the (Z)-isomer.
• Analytical Testing: Employed as a high-purity standard in HPLC, LC-MS, and NMR for quantifying impurities and ensuring batch-to-batch consistency in commercial cinnarizine production.
• Academic Research: Used in university and institutional labs for chemical, pharmacological, and toxicological research projects.

Basic Information

Product Name	(Z)-Cinnarizine
CAS No.	750512-44-8
Molecular Formula	C26H28N2
Molecular Weight	368.52 g/mol
Synonyms	1-(Diphenylmethyl)-4-[(Z)-3-phenyl-2-propen-1-yl]piperazine; (Z)-1-Cinnamyl-4-(diphenylmethyl)piperazine; cis-Cinnarizine; Z-Cinnarizine; (Z)-Cinnarizine Isomer; (2Z)-1-Cinnamyl-4-(diphenylmethyl)piperazine; Cinnarizine (Z)-isomer
EINECS	Contact for details

Quality Control

Our (Z)-Cinnarizine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC, Chiral)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.