Description

Nemadipine B is a high-purity pharmaceutical intermediate and research chemical, identified by CAS NO 79925-38-5. It serves as a critical building block in the synthesis of advanced calcium channel blockers and other active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical R&D laboratories, process development chemists, and manufacturers specializing in cardiovascular and neurological therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of dihydropyridine-class calcium channel blockers.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and new drug discovery programs.
• Process Chemistry: Serves as a reference standard and starting material for scaling up API manufacturing processes.
• Analytical Standard: Employed as a high-purity standard for HPLC, LC-MS, and NMR method development and validation in quality control laboratories.

Basic Information

Product Name	Nemadipine B
CAS No.	79925-38-5
Molecular Formula	C18H19N3O6
Molecular Weight	373.36 g/mol
Synonyms	Nemadipine B; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-(1-methylethyl) ester; Isopropyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(1-methylethyl) ester; 79925-38-5
EINECS	Contact for details

Quality Control

Our Nemadipine B is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all test results against established specifications to ensure compliance with research and pharmaceutical-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.