Description

Pivalopril CAS NO 76963-39-8 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant importance in medicinal chemistry. Its primary value lies in its role as a key building block for the synthesis of advanced angiotensin-converting enzyme (ACE) inhibitors and other cardiovascular drugs. This compound is essential for pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent ACE inhibitor drugs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used as a core structural component in the manufacture of final drug substances for hypertension and heart failure treatments.
• Medicinal Chemistry Research: Serves as a valuable scaffold for designing and developing novel protease inhibitors and cardiovascular agents.
• Process Development & Scale-up: Employed in optimizing synthetic routes and scaling production from laboratory to commercial batch sizes.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Pivalopril
CAS No.	76963-39-8
Molecular Formula	C16H22N2O5
Molecular Weight	322.36 g/mol
Synonyms	Pivalopril; (S)-1-[(S)-2-[[(S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid; 2-Pyrrolidinecarboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-, (2S)-; SQ 26,991; Pivaloprilum; Pivaloprilo
EINECS	Contact for details

Quality Control

Our Pivalopril is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profile determination via HPLC, to meet stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.