Description

Lisinopril CAS NO 76547-98-3 is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor. It is a critical active pharmaceutical ingredient (API) used in the formulation of antihypertensive and heart failure medications. This high-purity compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) worldwide.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral solid dosage forms (tablets, capsules) for the treatment of hypertension.
• Cardiovascular Therapeutics: Formulation of drugs for congestive heart failure and improving survival post-myocardial infarction.
• Fixed-Dose Combination Drugs: Used in combination with other APIs, such as hydrochlorothiazide, for enhanced therapeutic effect.
• Pharmaceutical Research & Development: Serves as a reference standard and key intermediate in the development of new cardiovascular drugs and generic formulations.
• Clinical Trial Material: Supply of GMP-grade material for Phase I-III clinical studies.
• Veterinary Medicine: Application in veterinary pharmaceuticals for managing hypertension in companion animals.

Basic Information

Product Name	Lisinopril
CAS No.	76547-98-3
Molecular Formula	C21H31N3O5•2H2O
Molecular Weight	441.52 g/mol (dihydrate)
Synonyms	N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline; (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-proline; Lisinopril Dihydrate; Prinivil; Zestril; Carace; Acerbon; Longes; Tersif
EINECS	Contact for details

Quality Control

Our Lisinopril is manufactured under strict quality management systems. It is typically tested to meet or exceed major pharmacopoeial standards, including USP, EP, and BP monographs. Each batch undergoes comprehensive analytical testing for identity, purity, and impurities. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF)	7.0% - 9.0% (for dihydrate)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%
Specific Rotation	-42.0° to -47.0° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.