Description

(S)-1-[n-[1-(Ethoxycarbonyl)-3-Phenylpropyl]-L-Alanyl]-L-Proline Maleate is a high-purity, non-peptide angiotensin-converting enzyme (ACE) inhibitor intermediate of significant pharmaceutical importance. This compound is a critical chiral building block in the synthesis of advanced active pharmaceutical ingredients (APIs), valued for its precise stereochemistry and structural complexity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of cardiovascular therapeutics, including next-generation antihypertensive drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of advanced ACE inhibitor APIs for cardiovascular disease treatment.
• Research & Development: Used in medicinal chemistry for the design, optimization, and structure-activity relationship (SAR) studies of novel protease inhibitors.
• Process Chemistry: Serves as a critical starting material or intermediate in scale-up and commercial manufacturing processes for target molecules.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Research: Used in enzymatic studies to investigate the mechanism of action and inhibition kinetics of ACE and related enzymes.

Basic Information

Item	Detail
Product Name	(S)-1-[n-[1-(Ethoxycarbonyl)-3-Phenylpropyl]-L-Alanyl]-L-Proline Maleate
CAS No.	76420-75-2
Molecular Formula	C23H30N2O6 • C4H4O4
Molecular Weight	542.55 g/mol
Synonyms	Lisinopril Maleate Intermediate; (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (Z)-butenedioate; Lisinopril Related Compound; 1-[N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-proline maleate salt; ACE Inhibitor Intermediate A; SQ 29,852 Maleate; N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline maleate; (S)-1-[N2-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-lysyl]-L-proline maleate
EINECS	Contact for details

Quality Control

Our (S)-1-[n-[1-(Ethoxycarbonyl)-3-Phenylpropyl]-L-Alanyl]-L-Proline Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical synthesis and research. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The original container should be kept tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.