Description

Enalaprilat is the active diacid metabolite of the prodrug Enalapril, functioning as a potent and competitive inhibitor of angiotensin-converting enzyme (ACE). This compound is critical for the development and quality control of cardiovascular pharmaceuticals, particularly antihypertensive agents. It is primarily required by pharmaceutical manufacturers, research institutions, and quality control laboratories engaged in drug synthesis, analytical method development, and reference standard applications.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Serves as the direct-acting metabolite in the formulation of certain antihypertensive medications.
• Reference Standard: Used as a high-purity calibrant in analytical laboratories for HPLC, LC-MS, and other chromatographic methods to quantify Enalapril and its metabolites.
• Biochemical Research: Employed in pharmacological and pharmacokinetic studies to investigate ACE inhibition mechanisms and metabolic pathways.
• Pharmaceutical Impurity Standard: Critical for identifying and quantifying related substances and degradation products in Enalapril maleate drug substance and finished dosage forms.
• Process Development & Validation: Utilized in the development and validation of synthetic routes and purification processes for ACE inhibitor drugs.

Basic Information

Product Name	Enalaprilat
CAS No.	76420-72-9
Molecular Formula	C18H24N2O5
Molecular Weight	348.40 g/mol
Synonyms	(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline; MK-422; Enalapril Diacid; Enalaprilat Dihydrate; Vasotec Impurity C; (S)-1-(N-(1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline; N-[(S)-1-Carboxy-3-phenylpropyl]-L-Ala-L-Pro
EINECS	Contact for details

Quality Control

Our Enalaprilat is produced and tested under strict quality management systems. We offer material suitable for research and pharmaceutical development, with typical purity levels exceeding 98% (HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Specifications can be aligned with in-house pharmacopeial standards (e.g., USP, EP) for reference material applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.