Description

(S)-Nicardipine CAS NO 76093-36-2 is the single enantiomer of the dihydropyridine calcium channel blocker, nicardipine. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure pharmaceuticals, offering superior specificity and reduced side-effect profiles compared to racemic mixtures. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing next-generation cardiovascular therapeutics and advanced drug delivery systems.

Application

• Key chiral building block for the synthesis of enantiopure (S)-Nicardipine hydrochloride, an L-type calcium channel antagonist.
• Critical intermediate in pharmaceutical research for developing novel cardiovascular drugs with improved efficacy and safety.
• Reference standard for analytical method development and quality control in chiral separation techniques (e.g., Chiral HPLC).
• Used in preclinical and clinical studies to investigate the pharmacodynamics and pharmacokinetics of the (S)-enantiomer.
• Starting material for process chemistry optimization and scale-up in GMP-compliant active pharmaceutical ingredient (API) manufacturing.
• Tool compound in biochemical assays for studying calcium channel function and receptor binding studies.

Basic Information

Product Name	(S)-Nicardipine
CAS No.	76093-36-2
Molecular Formula	C26H29N3O6
Molecular Weight	479.52 g/mol
Synonyms	(S)-Nicardipine; (S)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester; (S)-3-[2-(Benzylmethylamino)ethyl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (S)-Bay e 9736; (S)-YC-93; L-Nicardipine; (-)-Nicardipine; (S)-Nicardipine free base
EINECS	Contact for details

Quality Control

Our (S)-Nicardipine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting standards for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.