Description

(R)-(-)-Nicardipine CAS NO 76093-35-1 is the single enantiomer form of the dihydropyridine calcium channel blocker, nicardipine. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure pharmaceuticals, where the biological activity is often specific to one stereoisomer. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on cardiovascular drug discovery and advanced chiral synthesis.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiopure calcium channel antagonists.
• Cardiovascular Research: Used as a reference standard and active material in preclinical studies targeting hypertension and angina.
• Chiral Catalyst & Ligand Development: Serves as a precursor or model compound for developing asymmetric synthesis methodologies.
• Analytical Standard: Employed in HPLC and LC-MS methods for the quantification and purity assessment of nicardipine and related compounds.
• Metabolite Studies: Used in the investigation of metabolic pathways and the synthesis of drug metabolites for pharmacokinetic research.

Basic Information

Product Name	(R)-(-)-Nicardipine
CAS No.	76093-35-1
Molecular Formula	C26H29N3O6
Molecular Weight	479.52 g/mol
Synonyms	(R)-Nicardipine; (R)-(-)-Nicardipine Hydrochloride; (R)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester; (R)-3-[2-(Benzylmethylamino)ethyl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (R)-Bay e 9736; (R)-YC-93; (-)-Nicardipine
EINECS	Contact for details

Quality Control

Our (R)-(-)-Nicardipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) documenting identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.