Description

Enalapril CAS NO 75847-73-3 is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor widely recognized for its therapeutic efficacy. It is a critical active pharmaceutical ingredient (API) essential for the formulation of antihypertensive and heart failure medications. This compound is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug development and production.

Application

• Pharmaceutical API: Primary use as the active ingredient in tablets and other dosage forms for treating hypertension (high blood pressure).
• Cardiovascular Therapeutics: Formulation of medications for congestive heart failure and left ventricular dysfunction.
• Generic Drug Manufacturing: Sourcing for the production of cost-effective generic versions of branded ACE inhibitor drugs.
• Clinical Research: Utilization in preclinical and clinical studies for new cardiovascular drug combinations and delivery systems.
• Reference Standard: Served as a high-purity analytical standard in quality control laboratories for HPLC and spectroscopic assays.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing hypertension in companion animals.

Basic Information

Product Name	Enalapril
CAS No.	75847-73-3
Molecular Formula	C20H28N2O5
Molecular Weight	376.45 g/mol
Synonyms	Enalapril Maleate (salt form); MK-421; Vasotec (brand name); (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline; Enalaprilum; Enalapril Base; Enalapril Free Base; N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline 1'-Ethyl Ester
EINECS	Contact for details

Quality Control

Our Enalapril is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing including identification, assay, and impurity profiling to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for critical parameters like related substances, residual solvents, and heavy metals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.