Description

Nilvadipine is a potent dihydropyridine-class calcium channel blocker primarily used in pharmaceutical research and development. This compound is critical for its selective action on vascular smooth muscle, making it a key intermediate and active pharmaceutical ingredient (API) in the study and formulation of antihypertensive and antianginal medications. It is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on cardiovascular drug discovery and production.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in the manufacture of antihypertensive medications.
• Cardiovascular Research: Critical reference standard and biochemical tool in preclinical studies for vascular diseases.
• Analytical Standard: Serves as a high-purity standard for quality control and method validation in analytical laboratories (HPLC, LC-MS).
• Formulation Development: Used in the development of various dosage forms, including tablets and capsules.
• Chemical Intermediate: Acts as a key synthetic intermediate for further chemical modifications and derivative synthesis.
• Regulatory Submissions: Provides certified material for stability studies and regulatory documentation (e.g., FDA, EMA dossiers).

Basic Information

Product Name	Nilvadipine
CAS No.	75530-68-6
Molecular Formula	C19H19N3O6
Molecular Weight	385.37 g/mol
Synonyms	FK 235; FR 34235; Nivadipine; (±)-Nilvadipine; 5-Isobutyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-(2-methylpropyl) ester; ARCALION 200
EINECS	Contact for details

Quality Control

Our Nilvadipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles as per in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.