Description

L-Diltiazem is the pharmacologically active enantiomer of the calcium channel blocker Diltiazem. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure cardiovascular pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on producing advanced therapeutic agents for hypertension and angina. Our product, L-Diltiazem CAS NO 75472-92-3, is supplied to meet the stringent quality requirements of the global pharmaceutical supply chain.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure Diltiazem hydrochloride and related cardiovascular APIs.
• Research & Development: Used in pharmacological studies to investigate the specific activity, metabolism, and receptor binding of the L-enantiomer.
• Process Chemistry: Serves as a critical starting material or intermediate in optimized, asymmetric synthetic routes for scale-up production.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, and chiral separation methods for quality control and method development.
• Drug Discovery: A valuable scaffold for medicinal chemists exploring new chemical entities targeting L-type calcium channels.

Basic Information

Product Name	L-Diltiazem
CAS No.	75472-92-3
Molecular Formula	C22H26N2O4S
Molecular Weight	414.52 g/mol
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-4-methyl-1,5-benzothiazepin-3-ol; (-)-cis-Diltiazem; L-cis-Diltiazem; (2S,3S)-Diltiazem; Desacetyldiltiazem; Diltiazem Base; Diltiazem Free Base; Cardizem Intermediate
EINECS	Contact for details

Quality Control

Our L-Diltiazem is manufactured under strict quality management systems. Each batch is tested to ensure high chemical and enantiomeric purity, with specifications aligned with pharmaceutical intermediate requirements. A comprehensive Certificate of Analysis (COA) is provided for every shipment, detailing results for identity, purity, chiral purity, and related substances by validated methods such as HPLC and chiral chromatography.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.