Description

Icrf 198 CAS NO 75459-34-6 is a high-purity chemical compound, specifically a bisdioxopiperazine derivative, known for its role as a topoisomerase II inhibitor. This compound is critical for research and development in oncology and molecular biology, where precise biochemical tools are required. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cancer therapeutics and DNA replication studies.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel chemotherapeutic agents.
• Biochemical Research: Used as a potent tool compound in molecular biology to study topoisomerase II enzyme function, DNA replication, and cell cycle arrest mechanisms.
• Oncology Studies: Employed in in vitro and in vivo cancer research models to investigate tumor cell apoptosis and evaluate potential anti-cancer drug efficacy.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Academic Research: Utilized in university and institutional labs for fundamental studies on DNA topology and the mechanisms of action of topoisomerase inhibitors.

Basic Information

Product Name	Icrf 198
CAS No.	75459-34-6
Molecular Formula	C24H30N4O8
Molecular Weight	502.52 g/mol
Synonyms	ICRF-198; ICRF 198; (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; Dexrazoxane impurity; Bisdioxopiperazine derivative; Topoisomerase II inhibitor; NSC 169780; Razoxane impurity
EINECS	Contact for details

Quality Control

Our Icrf 198 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and full traceability are provided to ensure compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.