Description

Zofenoprilat is the active metabolite of the prodrug Zofenopril, representing a critical angiotensin-converting enzyme (ACE) inhibitor. This compound is of paramount importance in pharmaceutical research and development for its potent and long-lasting antihypertensive and cardioprotective effects. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in cardiovascular drug development, metabolic studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Active Ingredient (API) Intermediate: A key synthetic precursor in the commercial production of Zofenopril calcium, a widely prescribed ACE inhibitor medication.
• Cardiovascular Research: Used as a reference standard and investigational compound in preclinical and clinical studies targeting hypertension, heart failure, and myocardial infarction.
• Metabolic Pathway Analysis: Employed in pharmacokinetic and pharmacodynamic studies to understand the in vivo conversion and activity profile of prodrug ACE inhibitors.
• Analytical Reference Standard: Serves as a high-purity calibrant in quality control laboratories for HPLC, LC-MS, or other analytical methods to assay Zofenopril and related formulations.
• Biochemical Assay Development: Utilized in enzymatic assays to study ACE inhibition kinetics and screen for new inhibitory compounds.
• Chemical Synthesis: Acts as a sophisticated building block for medicinal chemists synthesizing novel ACE inhibitor analogs and hybrid molecules.

Basic Information

Product Name	Zofenoprilat
CAS No.	75176-37-3
Molecular Formula	C22H23NO4S2
Molecular Weight	429.56 g/mol
Synonyms	(4S)-1-[(2S)-3-Benzoylthio-2-methylpropanoyl]-4-(phenylthio)-L-proline; SQ 26,991; Zofenopril Diacid; Zofenopril Free Acid; (S)-1-[(S)-3-(Benzoylthio)-2-methylpropionyl]-4-(phenylthio)-L-proline; Zofenoprilat Calcium; Zofenopril Metabolite
EINECS	Contact for details

Quality Control

Our Zofenoprilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and HPLC, assay determination, and control of related substances and residual solvents, to ensure it meets high-purity standards suitable for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the container should be stored in a cool, dry place, ideally at controlled room temperature (15-25°C). For long-term storage under inert atmosphere, please contact our technical team.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.