Description

Methyl 2,2,2-Trifluoroethyl 4-(2-Chlorophenyl)-1,4-Dihydro-2,6-Dimethylpyridine-3,5-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the cardiovascular and antihypertensive therapeutic classes. It is essential for pharmaceutical R&D laboratories, process development chemists, and manufacturers requiring a reliable supply of high-quality, structurally complex intermediates for scale-up and production.

Application

• Key Intermediate in API Synthesis: Primarily used in the multi-step synthesis of dihydropyridine calcium channel blockers and related cardiovascular drugs.
• Pharmaceutical Research & Development: Serves as a crucial scaffold for medicinal chemists exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable manufacturing routes for target molecules.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis Building Block: Provides a versatile starting point for the preparation of specialized derivatives and analogs for biological screening.

Basic Information

Product Name	Methyl 2,2,2-Trifluoroethyl 4-(2-Chlorophenyl)-1,4-Dihydro-2,6-Dimethylpyridine-3,5-Dicarboxylate
CAS No.	74687-14-2
Molecular Formula	C19H17ClF3NO4
Molecular Weight	415.79 g/mol
Synonyms	4-(2-Chlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 2,2,2-trifluoroethyl ester; 2,2,2-Trifluoroethyl methyl 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; 4-(o-Chlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 2,2,2-trifluoroethyl ester; Dihydropyridine trifluoroethyl ester derivative; Felodipine related intermediate; CAS 74687-14-2
EINECS	Contact for details

Quality Control

Our Methyl 2,2,2-Trifluoroethyl 4-(2-Chlorophenyl)-1,4-Dihydro-2,6-Dimethylpyridine-3,5-Dicarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.