Description

Alacepril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used primarily as an active pharmaceutical ingredient (API). Its primary value lies in its effectiveness for managing hypertension and congestive heart failure by modulating the renin-angiotensin-aldosterone system. This compound is essential for pharmaceutical manufacturers and research institutions developing cardiovascular medications and conducting related pharmacological studies. Alacepril CAS NO 74258-86-9 is supplied under stringent quality controls to ensure reliability for critical therapeutic applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive and heart failure medications.
• Cardiovascular Research: A key reference standard and tool compound for studying ACE inhibition mechanisms and pharmacokinetics.
• Drug Formulation Development: Used in R&D for developing new oral dosage forms, such as tablets and capsules.
• Metabolite Studies: Serves as a precursor for the in-vivo formation of its active metabolite, deacetylalacepril, in metabolic pathway research.
• Analytical Reference Standard: Employed in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.
• Comparative Pharmacology: Used in studies comparing the efficacy and side-effect profiles of different ACE inhibitor classes.

Basic Information

Product Name	Alacepril
CAS No.	74258-86-9
Molecular Formula	C20H28N2O5S
Molecular Weight	408.51 g/mol
Synonyms	Alacepril; DU-1219; Cetapril; (S)-1-[6-Amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline, Phenylbutyryl Ester; 1-[(S)-3-Acetylthio-2-methylpropanoyl]-L-proline, 1-[[(Phenylbutyl)hydroxyphosphinyl]oxy]methyl Ester; L-Proline, 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-, 1-[[[4-phenylbutyl)hydroxyphosphinyl]oxy]methyl] ester
EINECS	Contact for details

Quality Control

Our Alacepril is manufactured and tested to meet high-purity standards suitable for pharmaceutical research and development. Each batch undergoes rigorous analytical testing, including HPLC for assay and purity, identification by spectroscopic methods, and control of specified impurities. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against established specifications. We adhere to a cGMP-compliant quality management system to ensure traceability, consistency, and regulatory support for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.