Description

4-(2,3-Dichlorophenyl)-1,4-Dihydro-2,6-Dimethyl-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-(1-Methylethyl) Ester is a high-purity dihydropyridine derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical pharmaceutical intermediate for the development of calcium channel blockers and other active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of cardiovascular and neurological therapeutics.

Application

• Key Intermediate in API Synthesis: Primary building block for the manufacture of dihydropyridine-class calcium channel antagonist drugs.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new therapeutic candidates targeting ion channels.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for commercial drug production.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Chemical Biology Studies: Utilized as a tool compound to study calcium signaling pathways and related physiological processes.

Basic Information

Product Name	4-(2,3-Dichlorophenyl)-1,4-Dihydro-2,6-Dimethyl-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-(1-Methylethyl) Ester
CAS No.	74073-24-8
Molecular Formula	C21H23Cl2NO4
Molecular Weight	424.32 g/mol
Synonyms	Isopropyl Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-Methyl 5-(1-Methylethyl) 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester; Dihydropyridine Derivative CAS 74073-24-8; 2,6-Dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-isopropyl ester
EINECS	Contact for details

Quality Control

Our 4-(2,3-Dichlorophenyl)-1,4-Dihydropyridine Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.