Description

Darodipine CAS NO 72803-02-2 is a high-purity pharmaceutical intermediate and research chemical belonging to the dihydropyridine class of calcium channel blockers. It is a critical building block in the synthesis and development of advanced cardiovascular drugs targeting hypertension and angina. This compound is essential for pharmaceutical R&D laboratories, API manufacturers, and academic institutions engaged in cardiovascular research and novel drug formulation.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of active pharmaceutical ingredients (APIs) for calcium channel antagonist drugs.
• Cardiovascular Research: Used as a reference standard and experimental compound in pharmacological studies investigating vasodilation, blood pressure regulation, and cardiac function.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and method development in analytical laboratories using HPLC, LC-MS, or NMR.
• Process Development: Employed in scaling up and optimizing synthetic routes for dihydropyridine derivatives within process chemistry and chemical engineering.
• Academic & Institutional Research: Utilized in universities and research institutes for studying structure-activity relationships (SAR) of calcium channel modulators.

Basic Information

Product Name	Darodipine
CAS No.	72803-02-2
Molecular Formula	C19H20N2O6
Molecular Weight	372.37 g/mol
Synonyms	Darodipine; PY 108-068; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester; Ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester; Diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; CAS 72803-02-2
EINECS	Contact for details

Quality Control

Our Darodipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and research chemicals. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.