Description

Felodipine is a potent and highly selective dihydropyridine calcium channel blocker used primarily as an antihypertensive agent. Its core value lies in its ability to effectively lower blood pressure by relaxing vascular smooth muscle with minimal impact on cardiac contractility, offering a favorable therapeutic profile. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing extended-release tablet formulations for the treatment of hypertension. Our supply of Felodipine CAS NO 72509-76-3 ensures high purity and consistent quality for reliable drug production.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive medications.
• Hypertension Treatment: Formulated into extended-release tablets for controlled, 24-hour blood pressure management.
• Cardiovascular Drug Development: Used in R&D for new drug formulations and combination therapies targeting cardiovascular diseases.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded felodipine products.
• Clinical Trial Materials: Supply of GMP-grade material for Phase I-IV clinical studies.
• Reference Standard: High-purity grade for use as a chromatographic reference standard in quality control laboratories.

Basic Information

Product Name	Felodipine
CAS No.	72509-76-3
Molecular Formula	C18H19Cl2NO4
Molecular Weight	384.25 g/mol
Synonyms	Felodipine; (±)-Felodipine; Plendil (Brand Name); 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester; Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; H 154/82; NSC 349224
EINECS	Contact for details

Quality Control

Our Felodipine is manufactured and tested under strict quality management systems. We offer material compliant with major pharmacopoeial standards, including USP and EP monographs. Every batch undergoes rigorous analytical testing for identity, purity, and impurities to ensure it meets the stringent requirements for pharmaceutical use. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specification results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). Keep the container in a dry, well-ventilated area. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.