Description

Bis{2-[Benzyl(Methyl)Amino]Ethyl} 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Dihydrochloride is a high-purity, dihydropyridine-based chemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its structural complexity and potential as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating new molecular entities and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the research and synthesis of novel calcium channel blockers and other dihydropyridine-class drug candidates.
• Chemical Biology Research: Used as a probe or building block in medicinal chemistry programs for structure-activity relationship (SAR) studies and target identification.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic pathways for new chemical entities under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Academic Research: Utilized in university and institutional labs for fundamental studies on heterocyclic chemistry and drug design principles.
• Custom Synthesis: Acts as a starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific research projects.

Basic Information

Item	Detail
Product Name	Bis{2-[Benzyl(Methyl)Amino]Ethyl} 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Dihydrochloride
CAS No.	71784-27-5
Molecular Formula	C38H44N4O6 · 2HCl
Molecular Weight	717.70 g/mol (Free base: 652.79 g/mol)
Synonyms	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid bis[2-(benzylmethylamino)ethyl] ester dihydrochloride; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid bis[2-(N-benzyl-N-methylamino)ethyl] ester dihydrochloride; BAY e 9736 dihydrochloride; (Benzylmethylamino)ethyl ester derivative dihydrochloride; 3-Nitrophenyl DHP derivative; Dihydropyridine diester dihydrochloride salt
EINECS	Contact for details

Quality Control

Our Bis{2-[Benzyl(Methyl)Amino]Ethyl} 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Dihydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.