Description

Amifostine Hydrate is an organothiophosphate prodrug and a potent cytoprotective agent. It is a critical pharmaceutical intermediate and active ingredient valued for its ability to selectively protect healthy tissues from the damaging effects of radiation therapy and certain chemotherapeutic agents. This compound is essential for manufacturers in the pharmaceutical and biotechnology sectors developing radioprotective and chemoprotective formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in injectable formulations for cytoprotection.
• Radioprotective Agent: Used in the development of drugs aimed at reducing side effects in patients undergoing radiation therapy for cancer.
• Chemoprotective Agent: Incorporated into therapeutic regimens to mitigate nephrotoxicity and ototoxicity associated with cisplatin chemotherapy.
• Research & Development: Serves as a key reference standard and intermediate in preclinical and clinical research for oncology support care.
• Biochemical Research: Utilized in studies investigating mechanisms of cellular protection against oxidative stress and apoptosis.

Basic Information

Product Name	Amifostine Hydrate
CAS No.	63717-27-1
Molecular Formula	C5H15N2O3PS • xH2O
Molecular Weight	214.22 g/mol (anhydrous basis)
Synonyms	Ethiofos; Ethyol (trade name); Gammaphos; WR-2721; S-2-(3-Aminopropylamino)ethylphosphorothioate; Amifostine Trihydrate; 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester
EINECS	Contact for details

Quality Control

Our Amifostine Hydrate is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications. Comprehensive testing includes identity confirmation, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting compliance with agreed specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.