Description

Nisoldipine CAS NO 63675-72-9 is a potent and selective calcium channel blocker belonging to the dihydropyridine class. This compound is of significant commercial and research interest for its specific pharmacological activity in modulating vascular tone. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in cardiovascular drug development and formulation.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of antihypertensive and antianginal medications.
• Reference Standard: Used in analytical laboratories for quality control, method development, and validation of pharmaceutical products.
• Biochemical Research: A critical tool for studying calcium channel physiology, vascular smooth muscle contraction, and related cardiovascular pathways.
• Drug Discovery & Development: Serves as a lead compound or comparator in the synthesis and screening of novel cardiovascular therapeutics.
• Controlled-Release Formulations: Employed in the development of advanced drug delivery systems to optimize pharmacokinetic profiles.

Basic Information

Product Name	Nisoldipine
CAS No.	63675-72-9
Molecular Formula	C28H28N2O7
Molecular Weight	504.53 g/mol
Synonyms	Bay k 5552; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, isobutyl methyl ester; 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl isobutyl ester; Isradipine analog; Sular (brand name); Syscor (brand name); (Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate)
EINECS	Contact for details

Quality Control

Our Nisoldipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at a controlled room temperature of 15-25°C to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.