Description

Mesudipine is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. Its primary value lies in its critical role as a key building block for the research and synthesis of advanced cardiovascular therapeutics. This compound is essential for pharmaceutical R&D laboratories, API manufacturers, and contract research organizations (CROs) focused on developing new drug formulations and generic medications. The material is supplied with full traceability and documentation to support regulatory filings and ensure batch-to-batch consistency.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacturing of calcium channel blocker APIs.
• Research & Development: Critical for medicinal chemistry programs targeting hypertension, angina, and other cardiovascular disorders.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Used in scale-up studies and optimization of synthetic routes for dihydropyridine derivatives.
• Academic Research: Employed in biochemical and pharmacological studies to investigate calcium channel mechanisms.
• Generic Drug Manufacturing: Integral component in the production of generic versions of established dihydropyridine-based drugs.

Basic Information

Product Name	Mesudipine
CAS No.	62658-88-2
Molecular Formula	C18H20N2O6
Molecular Weight	360.36 g/mol
Synonyms	Mesudipine; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-(1-methylethyl) ester; Isopropyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(1-methylethyl) ester; (±)-Mesudipine; rac-Mesudipine
EINECS	Contact for details

Quality Control

Our Mesudipine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets stringent pharmaceutical-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed-upon specifications and supporting regulatory requirements for GMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.