Description

Calcium Folinatc is the calcium salt of folinic acid (5-formyl tetrahydrofolic acid), a vital biochemical intermediate. This compound is crucial for its role in modulating folate metabolism and rescuing cells from the toxic effects of certain chemotherapeutic agents. It is primarily required by the pharmaceutical industry for the formulation of antidote and therapeutic drugs, as well as by research institutions for biochemical studies.

Application

• Pharmaceutical Antidote: Used in "leucovorin rescue" regimens to counteract the toxicity of folic acid antagonists like methotrexate in cancer chemotherapy.
• Oncology Therapeutics: A key component in combination therapies (e.g., with 5-fluorouracil) to enhance efficacy in treating colorectal and other cancers.
• Biochemical Research: Serves as a stabilized source of reduced folate in cell culture media and enzymatic studies of folate-dependent pathways.
• Hematology: Investigated for use in treating megaloblastic anemias and other conditions related to impaired folate metabolism.
• Veterinary Medicine: Applied in similar therapeutic and protective protocols for animals.
• Reference Standard: Used as a high-purity calibrant in analytical laboratories for quality control of pharmaceutical products.

Basic Information

Product Name	Calcium Folinatc
CAS No.	6035-45-6
Molecular Formula	C20H21CaN7O7
Molecular Weight	511.51 g/mol
Synonyms	Calcium Folinate; Calcium Leucovorin; Folinic Acid Calcium Salt; 5-Formyltetrahydrofolate Calcium Salt; Citrovorum Factor Calcium Salt; (6R)-5,10-Methenyltetrahydrofolate Calcium Salt; Antifolan; Leucovorin Calcium
EINECS	Contact for details

Quality Control

Our Calcium Folinatc is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to yellowish powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 8.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Microbial Limits	Meets Ph. Eur./USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.