Description

Amifostine Disodium is a highly specialized organothiophosphate cytoprotective agent. Its primary value lies in its ability to selectively protect healthy tissues from the damaging effects of radiation therapy and certain chemotherapeutic agents. This makes it a critical component in supportive care protocols within the pharmaceutical and oncology research sectors. Key users include manufacturers of active pharmaceutical ingredients (APIs), clinical research organizations, and institutions developing radioprotective formulations.

Application

• Oncological Supportive Care: As a cytoprotective adjuvant to reduce the incidence of moderate to severe xerostomia in patients undergoing postoperative radiation treatment for head and neck cancer.
• Chemotherapy Adjunct: To diminish the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer.
• Radioprotective Agent Manufacturing: Serves as the active pharmaceutical ingredient (API) in the production of finished injectable drug products designed for tissue protection.
• Preclinical & Clinical Research: Used in laboratory studies and clinical trials investigating mechanisms of cytoprotection, radioprotection, and mitigation of drug-induced toxicities.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate in the preparation of related organothiophosphate compounds with therapeutic potential.

Basic Information

Product Name	Amifostine Disodium
CAS No.	59178-37-9
Molecular Formula	C5H15N2Na2O3PS
Molecular Weight	272.19 g/mol
Synonyms	Ethiofos; Gammaphos; WR-2721; Amifostine; 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate (Ester) Disodium Salt; S-2-(3-Aminopropylamino)ethylphosphorothioic Acid Disodium Salt; NSC-296961; YM-08310
EINECS	Contact for details

Quality Control

Our Amifostine Disodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and application. Certificates of Analysis (COA) are provided, detailing parameters such as assay, related substances, residual solvents, and microbiological quality. We adhere to current industry best practices and can support development aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Meets standard bioburden limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.