Description

Tiapamil is a calcium channel blocker belonging to the benzothiazepine class of pharmaceutical compounds. It is primarily utilized as a key intermediate in the research and development of cardiovascular drugs, offering a critical building block for medicinal chemistry. This product is essential for pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in the synthesis of novel therapeutic agents targeting hypertension and angina.

Application

• Pharmaceutical Intermediate: Primary use as a high-purity building block in the synthesis of advanced calcium channel antagonist drugs.
• Cardiovascular Research: Critical reagent in preclinical and clinical research programs focused on heart disease, arrhythmias, and hypertension.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and the development of new benzothiazepine derivatives.
• Reference Standard: Serves as an analytical standard for quality control and regulatory compliance in pharmaceutical production.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing of specialized active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Tiapamil
CAS No.	57010-31-8
Molecular Formula	C20H28N2O3S
Molecular Weight	376.52 g/mol
Synonyms	(3S,5R)-3-[(3,4-Dimethoxyphenethyl)methylamino]-5-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one; Ro 11-1781; Tiapamil Hydrochloride (salt form); Tiapamilum; Dimethylverapamil; Benzothiazepine derivative
EINECS	Contact for details

Quality Control

Our Tiapamil is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality assurance includes comprehensive analytical testing against established specifications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.