Description

Nicardipine is a potent calcium channel blocker belonging to the dihydropyridine class, widely recognized for its vasodilatory effects. Its primary commercial value lies in its critical role as a key pharmaceutical intermediate and active pharmaceutical ingredient (API) for the formulation of antihypertensive and antianginal medications. This compound is essential for manufacturers in the pharmaceutical industry engaged in the production of cardiovascular drugs, as well as for research institutions conducting pharmacological studies. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final drug products derived from this intermediate.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of finished Nicardipine hydrochloride, a prescription medication.
• Active Pharmaceutical Ingredient (API): Used directly in the formulation of immediate-release and extended-release capsules for the treatment of hypertension and angina.
• Research & Development: Employed in preclinical and clinical studies to investigate cardiovascular pharmacology and develop new therapeutic agents.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.
• Chemical Synthesis: Acts as a model compound in organic chemistry for studying dihydropyridine synthesis and structure-activity relationships.

Basic Information

Product Name	Nicardipine
CAS No.	55985-32-5
Molecular Formula	C26H29N3O6
Molecular Weight	479.52 g/mol
Synonyms	Nicardipine Base; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester; (±)-Nicardipine; RS-Nicardipine; YC-93; Cardene (as the hydrochloride salt); Loxen (as the hydrochloride salt); Perdipine (as the hydrochloride salt)
EINECS	259-979-7

Quality Control

Our Nicardipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and support our products with detailed Certificates of Analysis (COA), which include results for identity, purity, and related substances. Specifications are aligned with common pharmacopeial requirements, and we can support documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.