Description

Nicardipine Hydrochloride is a high-purity pharmaceutical active ingredient belonging to the dihydropyridine class of calcium channel blockers. It is a critical intermediate and active pharmaceutical ingredient (API) used in the formulation of cardiovascular medications. This compound is essential for manufacturers in the pharmaceutical industry requiring a reliable and consistent supply for the production of antihypertensive and antianginal drugs. Our product, Nicardipine Hydrochloride CAS NO 54527-84-3, is supplied under stringent quality control to meet the exacting standards of global pharmaceutical applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of finished dosage forms for the treatment of hypertension and angina pectoris.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control testing in pharmaceutical laboratories.
• Research & Development: Utilized in preclinical and clinical research for studying calcium channel pharmacology and developing new cardiovascular therapies.
• Generic Drug Manufacturing: A key component for companies producing generic versions of nicardipine-based medications.
• Hospital Formulation: Used in hospital pharmacy settings for the preparation of injectable solutions where immediate blood pressure control is required.

Basic Information

Product Name	Nicardipine Hydrochloride
CAS No.	54527-84-3
Molecular Formula	C26H29N3O6 • HCl
Molecular Weight	516.0 g/mol
Synonyms	Nicardipine HCl; (±)-Nicardipine Hydrochloride; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester hydrochloride; YC-93; Perdipine; Cardene; Vasonase; RS-69216; Lomerizine related compound A (Hydrochloride)
EINECS	Contact for details

Quality Control

Our Nicardipine Hydrochloride is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Quality is assured through a comprehensive battery of analytical tests including HPLC for assay and related substances, residual solvent analysis, and specific identification tests. A Certificate of Analysis (COA) is provided with each batch, detailing compliance with agreed specifications. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopoeial standards (USP/EP) as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened only under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.