Description

Flunarizine is a selective calcium channel blocker belonging to the diphenylpiperazine class. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of specialized neurological and cardiovascular therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on innovative drug formulations. Flunarizine CAS NO 52468-60-7 is supplied under stringent quality control to ensure batch-to-batch consistency for reliable production outcomes.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of prescription medications for migraine prophylaxis and vertigo management.
• Neurological Research: A key compound in preclinical and clinical studies investigating calcium channel modulation in cerebral ischemia and other CNS disorders.
• Cardiovascular Research: Used in research models to study vasodilation and the role of calcium influx in vascular smooth muscle cells.
• Reference Standard: Serves as a high-purity analytical standard for quality control laboratories in pharmacopoeial testing and method validation.
• Custom Synthesis: Acts as a starting material or intermediate for the synthesis of novel derivatives and related pharmaceutical compounds.
• Veterinary Pharmaceuticals: Investigated for potential applications in veterinary medicine for similar neurological indications.

Basic Information

Product Name	Flunarizine
CAS No.	52468-60-7
Molecular Formula	C26H26F2N2
Molecular Weight	404.50 g/mol
Synonyms	Flunarizine Dihydrochloride; (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine; R 14950; Sibelium; Fluorinated Cinnarizine; 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine; Flunarizin; Flunarizinum
EINECS	257-904-7

Quality Control

Our Flunarizine is manufactured under a quality management system aligned with ICH Q7 guidelines. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC and related substances methods, to ensure it meets stringent pharmacopoeial standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications for identity, purity, and strength.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Related Substances (HPLC)	Total impurities: NMT 0.5% Any individual impurity: NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.