Description

Folinic Acid is a metabolically active form of folic acid, also known as leucovorin, with the CAS registry number 58-05-9. This compound is a critical biochemical intermediate, essential for its role in one-carbon transfer reactions in nucleic acid synthesis and cellular metabolism. It is a vital raw material and active ingredient for the pharmaceutical, nutraceutical, and advanced research sectors, where consistent high purity and reliable supply are paramount.

Application

• Pharmaceutical Formulations: As the active pharmaceutical ingredient (API) in calcium folinate/leucovorin calcium preparations, used as an antidote to folic acid antagonists (e.g., methotrexate) and in combination chemotherapy regimens (e.g., 5-FU).
• Nutraceutical & Dietary Supplements: Incorporated into high-end supplement formulations targeting cellular health, methylation support, and as a bioavailable source of folate.
• Biochemical Research: Utilized as a key reagent in cell culture media and metabolic studies to investigate folate-dependent pathways, DNA synthesis, and cell proliferation.
• Diagnostic Reagents: Serves as a component in specialized diagnostic kits and assays for clinical laboratory testing.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for similar therapeutic purposes as in human medicine.

Basic Information

Product Name	Folinic Acid
CAS No.	58-05-9
Molecular Formula	C20H23N7O7
Molecular Weight	473.44 g/mol
Synonyms	Leucovorin; 5-Formyltetrahydrofolate; 5-CHO-THF; Citrovorum Factor; Calcium Folinate (as salt); (6S)-5,6,7,8-Tetrahydrofolinic Acid; (6S)-5-Formyl-5,6,7,8-tetrahydrofolic Acid; NSC-3590
EINECS	200-368-5

Quality Control

Our Folinic Acid is manufactured under strict quality management systems. We offer grades suitable for pharmaceutical and high-purity applications, with testing aligned to relevant pharmacopoeial standards (e.g., USP, EP). Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure it meets your specific requirements for research or production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to yellowish crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 8.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.