Description

Verapamil is a calcium channel blocker of the phenylalkylamine class, widely recognized for its critical role in cardiovascular medicine. Its primary value lies in its ability to modulate calcium ion influx, making it an essential active pharmaceutical ingredient (API) for the treatment of hypertension, angina, and certain cardiac arrhythmias. This compound is a fundamental building block for global pharmaceutical manufacturers engaged in the production of prescription medications. We supply high-purity Verapamil CAS NO 52-53-9 to support reliable and compliant drug development and manufacturing processes worldwide.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for cardiovascular therapies.
• Hypertension Treatment: Formulated into tablets and capsules to manage high blood pressure.
• Angina Pectoris Management: Used in medications to prevent and treat chest pain caused by reduced blood flow to the heart.
• Antiarrhythmic Agent: Incorporated into drugs to control certain types of irregular heartbeats (e.g., supraventricular tachycardia).
• Migraine Prophylaxis: Employed in some preventative treatments for migraine headaches.
• Research & Development: Serves as a key reference standard and intermediate in pharmacological and clinical research.
• Generic Drug Manufacturing: A critical component for producers of cost-effective generic cardiovascular medications.

Basic Information

Product Name	Verapamil
CAS No.	52-53-9
Molecular Formula	C27H38N2O4
Molecular Weight	454.60 g/mol
Synonyms	Verapamil Hydrochloride (common salt form); (±)-Verapamil; Iproveratril; Cordilox; Isoptin; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzenecetonitrile
EINECS	200-145-1

Quality Control

Our Verapamil is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling against relevant pharmacopeial standards such as USP and EP. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Rotation	-0.10° to +0.10° (c = 1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.