Description

Zosuquidar Hydrochloride is a potent and selective third-generation P-glycoprotein (P-gp) inhibitor used in pharmaceutical research and development. This compound is critical for investigating multidrug resistance (MDR) in cancer cells and enhancing the efficacy of chemotherapeutic agents. It is primarily utilized by pharmaceutical companies, academic research institutions, and contract research organizations (CROs) focused on oncology, pharmacology, and drug delivery systems.

Application

• Oncology Research: Used as a key pharmacological tool to study and overcome P-gp-mediated multidrug resistance in various cancer cell lines.
• Drug Development: Employed in preclinical studies to enhance the intracellular accumulation and efficacy of co-administered chemotherapeutic drugs.
• Pharmacokinetic Studies: Applied in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the role of efflux transporters at biological barriers like the blood-brain barrier.
• Biochemical Assays: Serves as a reference standard in functional assays to characterize P-gp inhibitor activity and screen for new MDR reversal agents.
• Academic Research: Utilized in university and institutional labs for fundamental research into transporter biology and cancer mechanisms.

Basic Information

Product Name	Zosuquidar Hydrochloride
CAS No.	474276-97-6
Molecular Formula	C32H31F2N3O2·HCl
Molecular Weight	564.07 g/mol
Synonyms	LY335979 Hydrochloride; Zosuquidar HCl; (R)-N-(Quinolin-8-yl)-2-(2-(4-(3,4-difluorobenzoyl)piperazin-1-yl)acetamido)-3-phenylpropanamide Hydrochloride; LY-335979; NSC 710464; P-gp Inhibitor LY335979; Multidrug Resistance Reversal Agent LY335979
EINECS	Contact for details

Quality Control

Our Zosuquidar Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.